Novel Carbohydrate
Analogues
Supplies of novel
carbohydrate analogues with interest for the inhibition of glycosidase enzymes
and potential for development as therapies for a range of diseases including
cancer, viral infections and diabetes are available under material transfer
agreements from the Department of Pharmacy at the University of Reading.
The compounds can
be provided to order and may be used by companies as part of a library.
Benefits:
·
The novel analogues are now available through the expertise of
researchers who have the know-how to manufacture.
·
Supplies can be manufactured to order in the milligram range.
·
Potential for broader research collaborations in the area of
medicinal chemistry
Applications:
As tools in the design and development of:
·
Agents which may limit
tumour progression
·
Carbohydrate based
therapies & management of diabetes
·
Biological
screens
Technical
Background:
Medicinal chemistry programmes have allowed rapid access to a range
of carbohydrate analogues and carbohydrate derivatives, using naturally
occurring carbohydrates as starting materials. A diverse range of these small
molecule products is available.
Availability:
Compounds are
available as research tools under material transfer agreements on a non-
exclusive basis.
Reference:
Synthesis and glycosidase inhibitory profiles of functionalised
morpholines and oxazepanes, P.A. Burland, H.M.I. Osborn, A. Turkson, Bioorg.
Med. Chem., 2011, 19, 5679-5692
Synthetic entry to functionalised morpholines and [1,4] oxazepanes
via reductive amination reactions of
carbohydrate derived dialdehydes, S.M. Clark, H.M.I. Osborn, Tetrahedron : Asymm., 2004, 15, 3643-3652.